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NikR C terminal nickel binding domain
NikR is a transcription factor that regulates nickel uptake. It consists of two dimeric DNA binding domains separated by a tetrameric regulatory domain that binds nickel. This domain corresponds to the C terminal regulatory domain which contains four nickel binding sites at the tetramer interface [1]. [1]. 12970756. Crystal structure of the nickel-responsive transcription factor NikR. Schreiter ER, Sintchak MD, Guo Y, Chivers PT, Sauer RT, Drennan CL;. Nat Struct Biol. 2003;10:794-799. (from Pfam)
CopG family ribbon-helix-helix protein
CopG family ribbon-helix-helix (RHH) protein similar to CopG/NikR family transcriptional regulators and to Bacillus subtilis antitoxin EndoAI (MazE), which inactivates the toxin EndoA (MazF), an mRNA interferase that cleaves mRNAs in a sequence-specific manner, resulting in cellular growth arrest
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