Protein Family Models

This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria [1]. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins [2]. [1]. 9371459. Unusual structure of the tonB-exb DNA region of Xanthomonas campestris pv. campestris: tonB, exbB, and exbD1 are essential for ferric iron uptake, but exbD2 is not. Wiggerich HG, Klauke B, Koplin R, Priefer UB, Puhler A;. J Bacteriol 1997;179:7103-7110. [2]. 3294803. Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escherichia coli. Sun TP, Webster RE;. J Bacteriol 1987;169:2667-2674. (from Pfam)

Date:

2024-10-16

The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score.

Gene:

tolR

Date:

2022-10-11

ExbD/TolR family protein similar to Pseudomonas aeruginosa Tol-Pal system protein TolR, part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Date:

2024-04-25