Protein Family Models

Members of this family catalyse the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54. [1]. 10425687. Crystal structure of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. Shumilin IA, Kretsinger RH, Bauerle RH;. Structure Fold Des 1999;7:865-875. (from Pfam)

Date:

2024-10-16

Catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis

Gene:

kdsA

Date:

2021-07-29

This HMM describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide.

Gene:

kdsA

Date:

2024-05-30

3-deoxy-8-phosphooctulonate synthase catalyzes the condensation reaction between arabinose 5-phosphate and phosphoenolpyruvate to synthesize 3-deoxy-D-manno-octulosonate-8-phosphate (KDO8P), the precursor of the 8-carbon sugar KDO, which is an essential component of gram-negative bacterial lipopolysaccharides

Date:

2023-02-16