Protein Family Models

MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each subunit fold contains a beta-sandwich of Ig-like topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel [1]. [1]. 14976314. The structure of a mycobacterial outer-membrane channel. Faller M, Niederweis M, Schulz GE;. Science. 2004;303:1189-1192. (from Pfam)

Date:

2024-10-16

MspA family protein may be a transmembrane channel-forming porin and transport cations across the cell membrane

Date:

2021-02-02