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Links from Protein

Items: 5

1.

methylenetetrahydrofolate reductase

This family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from bacteria and methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The structure for this domain is known [1] to be a TIM barrel. [1]. 10201405. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia [see comments]. Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML;. Nat Struct Biol 1999;6:359-365. (from Pfam)

GO Terms:
Molecular Function:
methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489)
Biological Process:
methionine metabolic process (GO:0006555)
Date:
2024-10-16
Family Accession:
NF014296.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:
3.
new record, indexing in progress
Family Accession:
4.

methylenetetrahydrofolate reductase

methylenetetrahydrofolate reductase catalyzes NADH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor

Date:
2017-03-20
Family Accession:
10002151
Method:
Sparcle
5.

methylenetetrahydrofolate reductase [NAD(P)H]

The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in bacteria, and currently designated 1.7.99.5. This protein is an FAD-containing flavoprotein.

Gene:
metF
GO Terms:
Molecular Function:
methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489)
Cellular Component:
cytosol (GO:0005829)
Biological Process:
methionine biosynthetic process (GO:0009086)
Date:
2024-05-30
Family Accession:
TIGR00676.1
Method:
HMM
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