Protein Family Models

The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus [1]. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localise Asp23 to the cell membrane [2]. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria. UniProtKB:Q2FW64 [2]. [1]. 7864904. Isolation and the gene cloning of an alkaline shock protein in methicillin resistant Staphylococcus aureus. Kuroda M, Ohta T, Hayashi H;. Biochem Biophys Res Commun 1995;207:978-984. [2]. 25074408. Deletion of membrane-associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus. Muller M, Reiss S, Schluter R, Mader U, Beyer A, Reiss W, Marles-Wright J, Lewis RJ, Pfortner H, Volker U, Riedel K, Hecker M, Engelmann S, Pane-Farre J;. Mol Microbiol. 2014;93:1259-1268. (from Pfam)

Date:

2024-10-16

Asp23/Gls24 family envelope stress response protein similar to Staphylococcus aureus alkaline shock protein 23 (Asp23) and Streptococcus pyogenes stress response regulator gls24 homolog

Date:

2023-03-14