Protein Family Models for Protein (Select 492864881) - Protein Family Models

Select item 4229131.

Branched-chain amino acid ATP-binding cassette transporter

This domain family is found in bacteria, archaea and eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00005. There is a conserved AYLG sequence motif. This family is the C terminal of an ATP dependent branched-chain amino acid transporter [1]. This domain is essential for LPS transport, through critical interactions with Walker A and switch helix domains [2]. [1]. 2195019. Nucleotide sequence and genetic characterization reveal six. essential genes for the LIV-I and LS transport systems of. Escherichia coli.. Adams MD, Wagner LM, Graddis TJ, Landick R, Antonucci TK, Gibson. AL, Oxender DL;. J Biol Chem 1990;265:11436-11443.. [2]. 31431556. Combining Mutations That Inhibit Two Distinct Steps of the ATP. Hydrolysis Cycle Restores Wild-Type Function in the. Lipopolysaccharide Transporter and Shows that ATP Binding. Triggers Transport.. Simpson BW, Pahil KS, Owens TW, Lundstedt EA, Davis RM, Kahne D,. Ruiz N;. mBio. 2019; [Epub ahead of print] (from Pfam)

Date:: 2024-08-14

Family Accession:: NF023816.5
Method:: HMM

Select item 4132122.

Branched-chain amino acid transport system / permease component

This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH Swiss:P08340 and LivM Swiss:P22729 both of which are form the LIV-I transport system [3]. Also found with in this family are proteins from the galactose transport system permease [2] and a ribose transport system [1]. [1]. 7921236. Analysis of a ribose transport operon from Bacillus subtilis.. Woodson K, Devine KM;. Microbiology 1994;140:1829-1838.. [2]. 1719366. Nucleotide sequence and analysis of the mgl operon of. Escherichia coli K12.. Hogg RW, Voelker C, Von Carlowitz I;. Mol Gen Genet 1991;229:453-459.. [3]. 2195019. Nucleotide sequence and genetic characterization reveal six. essential genes for the LIV-I and LS transport systems of. Escherichia coli.. Adams MD, Wagner LM, Graddis TJ, Landick R, Antonucci TK, Gibson. AL, Oxender DL;. J Biol Chem 1990;265:11436-11443. (from Pfam)

GO Terms:

Cellular Component:: membrane (GO:0016020)

Molecular Function:: transmembrane transporter activity (GO:0022857)

Biological Process:: transmembrane transport (GO:0055085)

Date:: 2024-08-14

Family Accession:: NF014684.5
Method:: HMM

Select item 4111433.

ATP-binding cassette domain-containing protein

ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains. [1]. 1864505. Homology between proteins controlling Streptomyces fradiae. tylosin resistance and ATP-binding transport.. Rosteck PR Jr, Reynolds PA, Hershberger CL;. Gene 1991;102:27-32.. [2]. 1977073. Structure and function of haemolysin B,P-glycoprotein and other. members of a novel family of membrane translocators.. Blight MA, Holland IB;. Mol Microbiol 1990;4:873-880.. [3]. 2229036. Binding protein-dependent transport systems.. Higgins CF, Hyde SC, Mimmack MM, Gileadi U, Gill DR, Gallagher. MP;. J Bioenerg Biomembr 1990;22:571-592.. [4]. 9872322. Crystal structure of the ATP-binding subunit of an ABC. transporter.. Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH;. Nature 1998;396:703-707. (from Pfam)

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Date:: 2024-08-14

Family Accession:: NF012235.5
Method:: HMM

Select item 3985164.