Protein Family Models

This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) [1] and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis [2]. [1]. 22000520. Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase. Roumestand C, Leiba J, Galophe N, Margeat E, Padilla A, Bessin Y, Barthe P, Molle V, Cohen-Gonsaud M;. Structure. 2011;19:1525-1534. [2]. 22275220. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T;. Sci Signal. 2012;5:ra7. (from Pfam)

Date:

2024-10-16

DUF3662 domain-containing protein similar to Mycobacterium tuberculosis protein Rv0020c (also called FhaA) that is one of the major substrates of the essential serine/threonine protein kinase PknB

Date:

2019-12-12