Protein Family Models

This entry includes Cytochrome c-type protein NrfB and similar proteins, which plays a role in nitrite reduction. These proteins contain several copies of the CXXCH haem-binding motif [1-5]. Paper describing PDB structure 1eys. [1]. 11095707. Crystal structures of photosynthetic reaction center and high-potential iron-sulfur protein from Thermochromatium tepidum, thermostability and electron transfer. Nogi T, Fathir I, Kobayashi M, Nozawa T, Miki K;. Proc Natl Acad Sci U S A 2000;97:13561-13566. Paper describing PDB structure 2czs. [2]. 16156654. Structural and biochemical characterization of DHC2, a novel diheme cytochrome c from Geobacter sulfurreducens. Heitmann D, Einsle O;. Biochemistry. 2005;44:12411-12419. Paper describing PDB structure 2ozy. [3]. 17521287. The crystal structure of the pentahaem c-type cytochrome NrfB and characterization of its solution-state interaction with the pentahaem nitrite reductase NrfA. Clarke TA, Cole JA, Richardson DJ, Hemmings AM;. Biochem J. 2007;406:19-30. Paper describing PDB structure 3wmm. [4]. 24670637. Structure of the LH1-RC complex from Thermochromatium tepidum at 3.0 A. Niwa S, Yu LJ, Takeda K, Hirano Y, Kawakami T, Wang-Otomo ZY, Miki K;. Nature. 2014;508:228-232. Paper describing PDB structure 6r2q. [5]. 32289252. The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire. Edwards MJ, White GF, Butt JN, Richardson DJ, Clarke TA;. Cell. 2020;181:665-673. (from Pfam)

Date:

2024-10-16

The HMM describes a tetraheme c-type cytochrome domain as found in cytochrome c-554, a protein involved in nitrification of ammonia in Nitrosomonas europaea. Proteins with this domain are multi-heme proteins.

Date:

2024-10-16

Part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia

Gene:

nrfB

Date:

2024-05-02

cytochrome c nitrite reductase pentaheme subunit plays a role in nitrite reduction

Date:

2019-08-23

Members of this protein family contain five copies of the CXXCH heme-binding motif, and are the NrfB component of the multisubunit enzyme, cytochrome c nitrite reductase.

Gene:

nrfB

Date:

2024-07-01