Protein Family Models

This family contains a wide variety of enzymes, principally acyl-CoA thioesterases. These enzymes are part of the Hotdog fold superfamily [1]. This entry is usually found as the N-terminal part of a pair of HotDog domains. [1]. 15307895. The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases. Dillon SC, Bateman A;. BMC Bioinformatics 2004;5:109-109. (from Pfam)

Date:

2024-10-16

This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters. [1]. 9837940. The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3. Benning MM, Wesenberg G, Liu R, Taylor KL, Dunaway-Mariano D, Holden HM;. J Biol Chem 1998;273:33572-33579. [2]. 8805534. Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. Leesong M, Henderson BS, Gillig JR, Schwab JM, Smith JL;. Structure 1996;4:253-264. (from Pfam)

Date:

2024-10-16

Gene:

yigI

Date:

2023-01-13

Date:

2020-10-26

thioesterase family protein similar to Escherichia coli protein YigI

Date:

2019-06-20

TIGR00369 describes a set of hotdog fold thioesterases, found either as stand-alone protein or as a domain of a multifunctional protein. Examples include EntH (the proofreading thioesterase of enterobactin biosynthesis), MenI (1,4-dihydroxy-2-naphthoyl-CoA hydrolase), and PaaI (hydroxyphenylacetyl-CoA thioesterase).

Date:

2021-10-26