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Polyphosphate kinase 2 (PPK2)
Inorganic polyphosphate (polyP) plays a role in metabolism and regulation and has been proposed to serve as a energy source in a pre-ATP world. In prokaryotes, the synthesis and utilisation of polyP are catalysed by PPK1, PPK2 and polyphosphatases. Proteins with a single PPK2 domain catalyse polyP-dependent phosphorylation of ADP to ATP, whereas proteins containing 2 fused PPK2 domains phosphorylate AMP to ADP. The structure of PPK2 from Pseudomonas aeruginosa has revealed a a 3-layer alpha/beta/alpha sandwich fold with an alpha-helical lid similar to the structures of microbial thymidylate kinases [3]. [1]. 12486232. A polyphosphate kinase (PPK2) widely conserved in bacteria. Zhang H, Ishige K, Kornberg A;. Proc Natl Acad Sci U S A 2002;99:16678-16683. [2]. 12482933. Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP. Ishige K, Zhang H, Kornberg A;. Proc Natl Acad Sci U S A 2002;99:16684-16688. [3]. 19001261. Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria. Nocek B, Kochinyan S, Proudfoot M, Brown G, Evdokimova E, Osipiuk J, Edwards AM, Savchenko A, Joachimiak A, Yakunin AF;. Proc Natl Acad Sci U S A. 2008;105:17730-17735. (from Pfam)
polyphosphate kinase 2 family protein
polyphosphate kinase 2 (PPK2) family protein similar to bacteria PPK2 that catalyzes the polyP-dependent phosphorylation of nucleoside diphosphates (ADP, GDP) to nucleoside triphosphates
PPK2 family polyphosphate kinase
Members of this protein family belong to the polyphosphate kinase 2 (PPK2) family, which is not related in sequence to PPK1. While PPK1 tends to act in the biosynthesis of polyphosphate, or poly(P), members of the PPK2 family tend to use the terminal phosphate of poly(P) to regenerate ATP or GTP from the corresponding nucleoside diphosphate, or ADP from AMP as is the case with polyphosphate:AMP phosphotransferase (PAP). Members of this protein family most likely transfer the terminal phosphate between poly(P) and some nucleotide, but it is not clear which.
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