Protein Family Models

The Swiss Army Knife class of proteins features a diverse domain repertoire acting to repair RNA damaged in the wake of RNase attacks. PTP-SAK is one such domain, a phosphatase of the rhodanese-phosphatase superfamily. It is predicted to 'clean' RNA ends by removing phosphate groups, preparing them for ligation by their associating RNA ligases [1,2]. [1]. 36968430. New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts. Burroughs AM, Aravind L;. NAR Genom Bioinform. 2023;5:lqad029. [2]. 27536007. RNA damage in biological conflicts and the diversity of responding RNA repair systems. Burroughs AM, Aravind L;. Nucleic Acids Res. 2016;44:8525-8555. (from Pfam)

Date:

2024-10-16

While the land plant version of this DSP-PTPase domain is likely inactive as the catalytic cysteine is replaced by serine or threonine, the rest are predicted to be active. Keeping with the proposed sugar phosphatase activity in related members, these domains could potentially function as phosphatases converting NADP to NAD+. [1]. 36968430. New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts. Burroughs AM, Aravind L;. NAR Genom Bioinform. 2023;5:lqad029. [2]. 24968225. Genome-wide analysis of the NADK gene family in plants. Li WY, Wang X, Li R, Li WQ, Chen KM;. PLoS One. 2014;9:e101051. (from Pfam)

Date:

2024-10-28

This family is closely related to the Pfam:PF00102 and Pfam:PF00782 families. (from Pfam)

Date:

2024-08-14