Protein Family Models

This domain is found in a number of proteins belonging to glycosyl hydrolase 2 family [1-5]. Paper describing PDB structure 1bhg. [1]. 8599764. Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs. Jain S, Drendel WB, Chen ZW, Mathews FS, Sly WS, Grubb JH;. Nat Struct Biol. 1996;3:375-381. Paper describing PDB structure 1dp0. [2]. 11045615. High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for alpha-complementation. Juers DH, Jacobson RH, Wigley D, Zhang XJ, Huber RE, Tronrud DE, Matthews BW;. Protein Sci. 2000;9:1685-1699. Paper describing PDB structure 1jyn. [3]. 11732897. A structural view of the action of Escherichia coli (lacZ) beta-galactosidase. Juers DH, Heightman TD, Vasella A, McCarter JD, Mackenzie L, Withers SG, Matthews BW;. Biochemistry. 2001;40:14781-14794. Paper describing PDB structure 1px3. [4]. 14621996. Structural basis for the altered activity of Gly794 variants of Escherichia coli beta-galactosidase. Juers DH, Hakda S, Matthews BW, Huber RE;. Biochemistry. 2003;42:13505-13511. Paper describing PDB structure 1yq2. [5]. 16171818. Cold-active beta-galactosidase from Arthrobacter sp. C2-2 forms compact 660 kDa hexamers: crystal structure at 1.9A resolution. Skalova T, Dohnalek J, Spiwok V, Lipovova P, Vondrackova E, Petrokova H, Duskova J, Strnad H, Kralova B, Hasek J;. J Mol Biol. 2005;353:282-294. (from Pfam)

Date:

2024-10-16

This domain belongs to the Concanavalin A-like lectin/glucanases superfamily. (from Pfam)

Date:

2024-08-14

This domain can be found in 2 glycoside hydrolase subfamily of beta-glucosaminidases (EC:3.2.1.165) such as CsxA, from Amycolatopsis orientalis that has exo-beta-D-glucosaminidase (exo-chitosanase) activity. It has an immunoglobulin-like topology [1]. [1]. 18976664. The structural basis of substrate recognition in an exo-beta-D-glucosaminidase involved in chitosan hydrolysis. van Bueren AL, Ghinet MG, Gregg K, Fleury A, Brzezinski R, Boraston AB;. J Mol Biol. 2009;385:131-139. (from Pfam)

Date:

2024-10-16

This domain corresponds to domain 4 in the structure of Bacteroides thetaiotaomicron beta-mannosidase, BtMan2A [1]. This domain has an Ig-like fold. [1]. 17287210. Mannose foraging by Bacteroides thetaiotaomicron: structure and specificity of the beta-mannosidase, BtMan2A. Tailford LE, Money VA, Smith NL, Dumon C, Davies GJ, Gilbert HJ;. J Biol Chem. 2007;282:11291-11299. (from Pfam)

Date:

2024-10-16

This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold. The domain binds the sugar moiety during the sugar-hydrolysis reaction. [1]. 8008071. Three-dimensional structure of beta-galactosidase from E. coli. Jacobson RH, Zhang XJ, DuBose RF, Matthews BW;. Nature. 1994;369:761-766. (from Pfam)

Date:

2024-10-16

This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities. [1]. 8008071. Three-dimensional structure of beta-galactosidase from E. coli. Jacobson RH, Zhang XJ, DuBose RF, Matthews BW;. Nature. 1994;369:761-766. (from Pfam)

Date:

2024-10-16