Protein Family Models

This is the C-terminal seven alpha helices of the structure whose full length represents the enzyme adenylosuccinate lyase. This sequence lies C-terminal to the conserved motif necessary for beta-elimination reactions [1], Adenylosuccinate lyase catalyses two steps in the synthesis of purine nucleotides: the conversion of succinylaminoimidazole-carboxamide ribotide into aminoimidazole-carboxamide ribotide, the eighth step of the de novo pathway, and the formation of adenosine monophosphate (AMP) from adenylosuccinate, the second step in the conversion of inosine monophosphate into AMP [2]. [1]. 9274883. Characterisation of the gene encoding adenylosuccinate lyase of Plasmodium falciparum. Marshall VM, Coppel RL;. Mol Biochem Parasitol. 1997;88:237-241. [2]. 17485188. Adenylosuccinate lyase deficiency: The first identified polish patient. Jurkiewicz E, Mierzewska H, Kusmierska K;. Brain Dev. 2007;29:600-602. (from Pfam)

Date:

2024-10-16

Members of this family include fumarate hydratase, L-aspartate ammonia-lyase, argininosuccinate lyase, and adenylosuccinate lyase. All are classified as lyases, meaning these enzymes break a bond by an eliminating reaction that does not involve hydrolysis or oxidation.

Date:

2024-08-14

adenylosuccinate lyase family protein similar to Acinetobacter sp. 3-carboxy-cis,cis-muconate cycloisomerase, which catalyzes the cyclization of 3-carboxy-cis,cis-muconate to 4-carboxy-muconolactone in the beta-ketoadipate pathway

Date:

2017-10-10