Protein Family Models

This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry [1]. The function of this domain appears to be to bind galactose [2], and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6 [3]. This domain is associated with the families GHMP_kinases_C, Pfam:PF08544 and GHMP_kinases_N, Pfam:PF00288. [1]. 10359639. The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core. Schalkwijk J, Wiedow O, Hirose S;. Biochem J. 1999;340:569-577. [2]. 12796487. Molecular structure of galactokinase. Thoden JB, Holden HM;. J Biol Chem. 2003;278:33305-33311. [3]. 15526155. Galactokinase: structure, function and role in type II galactosemia. Holden HM, Thoden JB, Timson DJ, Reece RJ;. Cell Mol Life Sci. 2004;61:2471-2484. (from Pfam)

Date:

2024-10-16

This family includes homoserine kinases, galactokinases and mevalonate kinases. (from Pfam)

Date:

2024-08-14

This family includes homoserine kinases, galactokinases and mevalonate kinases. (from Pfam)

Date:

2024-08-14

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Date:

2018-06-13

Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding. The galactokinases found by this HMM are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity.

Gene:

galK

Date:

2024-05-30