Protein Family Models

This domain has a tudor domain-like beta barrel fold. It is found in the FlgD protein the flagellar hook capping protein. The structure for this domain shows that it contains a nested Ig-like domain within it [1]. However in some firmicute proteins this inserted domain is absent such as Q67K21. [1]. 18599076. Crystal structure of the C-terminal domain of a flagellar hook-capping protein from Xanthomonas campestris. Kuo WT, Chin KH, Lo WT, Wang AH, Chou SH;. J Mol Biol. 2008;381:189-199. (from Pfam)

Date:

2024-10-16

This domains has an immunoglobulin like beta sandwich fold. It is found in the FlgD protein the flagellar hook capping protein. THe structure for this domain shows that it is inserted within a TUDOR like beta barrel domain [1]. [1]. 18599076. Crystal structure of the C-terminal domain of a flagellar hook-capping protein from Xanthomonas campestris. Kuo WT, Chin KH, Lo WT, Wang AH, Chou SH;. J Mol Biol. 2008;381:189-199. (from Pfam)

Date:

2024-10-16

FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum [1]. It appears to act as a hook-capping protein to enable assembly of hook protein subunits [1]. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerisation and also plays a role in determination of the correct hook length, with the help of the FliK protein [2]. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallisation [3]. [1]. 8157595. FlgD is a scaffolding protein needed for flagellar hook assembly in Salmonella typhimurium. Ohnishi K, Ohto Y, Aizawa S, Macnab RM, Iino T;. J Bacteriol 1994;176:2272-2281. [2]. 19652342. Cloning, purification, crystallization and preliminary X-ray studies of flagellar hook scaffolding protein FlgD from Pseudomonas aeruginosa PAO1. Luo M, Niu S, Yin Y, Huang A, Wang D;. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:795-797. [3]. 18599076. Crystal structure of the C-terminal domain of a flagellar hook-capping protein from Xanthomonas campestris. Kuo WT, Chin KH, Lo WT, Wang AH, Chou SH;. J Mol Biol. 2008;381:189-199. (from Pfam)

Date:

2024-10-16

Gene:

flgD

Date:

2022-06-01

flagellar hook assembly protein FlgD may act as a scaffolding protein required for flagellar hook formation

Date:

2018-03-22