Protein Family Models

This domain is found in fatty acid kinase subunit A (FakA) from a bacterial fatty acid kinase (Fak) system and it is localised between Pfam:PF02734 and Pfam:PF13684. Two major human pathogens, Staphylococcus and Streptococcus, use this machinery to scavenge host fatty acids [1]. The Fak complex consists of an ATP-binding subunit FakA, which interacts with varied FakB (fatty acid-binding protein) isoforms, and synthesises acyl-phosphate from extracellular fatty acids [1]. FakA comprises three domains, denoted as FakA_N, FakA_M and FakA_C in [1] of which the middle domain is represented in this entry. It consists of four alpha-helices, four beta-strands and several long loops, containing a zinc finger motif. It shows similarities to the yeast copper chaperone ATX1, a metallochaperone/metal-binding protein. [1]. 36054360. Structure and mechanism for streptococcal fatty acid kinase (Fak) system dedicated to host fatty acid scavenging. Shi Y, Zang N, Lou N, Xu Y, Sun J, Huang M, Zhang H, Lu H, Zhou C, Feng Y;. Sci Adv. 2022;8:eabq3944. (from Pfam)

Date:

2024-10-16

This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family. (from Pfam)

Date:

2024-08-14