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HU domain fused to wHTH, Ig, or Glycine-rich motif
Rapidly-diverging family of HU domains predominantly observed in the bacteroidetes lineage with a predicted role in recognition and possible interception of the DNA of parasitic elements, a counter-conflict strategy preventing incorporation of these elements into the host genome [1]. [1]. 28441108. Novel clades of the HU/IHF superfamily point to unexpected roles. in the eukaryotic centrosome, chromosome partitioning, and. biologic conflicts.. Burroughs AM, Kaur G, Zhang D, Aravind L;. Cell Cycle. 2017;16:1093-1103. (from Pfam)
HU family DNA-binding protein
HU family DNA-binding protein is a conserved nucleoid-associated protein, which binds non-specifically to duplex DNA with a particular preference for targeting nicked and bent DNA. It is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein
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