Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
BrnA antitoxin family protein
BrnA is family of antitoxins that neutralises the toxin BrnT, Pfam:PF04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerises with two molecules of its toxin BrnT [1]. [1]. 22334680. Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus. Heaton BE, Herrou J, Blackwell AE, Wysocki VH, Crosson S;. J Biol Chem. 2012;287:12098-12110. (from Pfam)
CopG family antitoxin
CopG antitoxin is a member of a type II toxin-antitoxin system family found in bacteria and archaea. Most antitoxins encoded by the relBE and parDE loci belong to the MetJ/Arc/CopG family of dimeric proteins which bind DNA through N-terminal ribbon-helix-helix (RHH) motifs [1]. The toxin for CopG proteins falls into the family BrnT_toxin, Pfam:PF04365. [1]. 15864262. Prokaryotic toxin-antitoxin stress response loci. Gerdes K, Christensen SK, Lobner-Olesen A;. Nat Rev Microbiol. 2005;3:371-382. (from Pfam)
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on