Protein Family Models

Members of this family are integral membrane proteins. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis [2]. [1]. 2549031. The sodium ion translocating oxaloacetate decarboxylase of Klebsiella pneumoniae. Sequence of the integral membrane-bound subunits beta and gamma. Laussermair E, Schwarz E, Oesterhelt D, Reinke H, Beyreuther K, Dimroth P;. J Biol Chem 1989;264:14710-14715. [2]. 9428714. Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and sequencing of the structural genes and purification of the enzyme complex. Bott M, Pfister K, Burda P, Kalbermatter O, Woehlke G, Dimroth P;. Eur J Biochem 1997;250:590-599. (from Pfam)

Date:

2024-10-16

sodium ion-translocating decarboxylase subunit beta such as oxalacetate decarboxylase subunit beta, which is part of the complex that acts as a lyase and sodium transporter

Date:

2018-04-16

This model describes the beta subunits of sodium pump decarboxylases that include oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, and glutaconyl-CoA decarboxylase. Beta and gammma-subunits are integral membrane proteins, while alpha is membrane bound. Catalytically, the energy released by the decarboxylation reaction is coupled to the extrusion of Na+ ions across the membrane.

Date:

2024-05-30