Protein Family Models for Protein (Select 497572868) - Protein Family Models

Select item 4328961.

exosome complex protein Rrp42 is a non-catalytic component of the exosome, which is a complex involved in RNA degradation

Date:: 2024-02-09

Family Accession:: 11450159
Method:: Sparcle

Select item 4152092.

3' exoribonuclease family, domain 2

This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria. [1]. 9390555. The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D;. Cell 1997;91:457-466. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF015670.5
Method:: HMM

Select item 4111873.

3' exoribonuclease family, domain 1

This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria. [1]. 9390555. The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D;. Cell 1997;91:457-466. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF013318.5
Method:: HMM

Select item 3916834.

new record, indexing in progress

Family Accession:

Select item 3893615.

new record, indexing in progress

Family Accession:

Select item 3497926.

new record, indexing in progress

Family Accession:

Select item 3470927.

new record, indexing in progress

Family Accession:

Select item 3360418.

exosome complex protein Rrp42

Rrp42 forms a trimer of heterodimers (hexamer) with Rrp41 which makes up the catalytic core of the archaeal exosome

Gene:: rrp42

GO Terms:

Cellular Component:: exosome (RNase complex) (GO:0000178)

Biological Process:: RNA catabolic process (GO:0006401)

Date:: 2022-01-04

Family Accession:: NF003282.1
Method:: HMM

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