Protein Family Models

This is the C-terminal thioredoxin like domain found in Rv2874 in the pathogenic bacterium Mycobacterium tuberculosis [1]. Structure analysis of Rv2874-C shows the presence of a C-terminal domain formed by the 128 residues Thr568-Gly695. These residues form a jelly-roll structure in which two antiparallel beta-sheets sandwich a hydrophobic core. This domain is combined with a second domain with a carbohydrate-binding module (CBM) fold [2]. [1]. 16511006. Crystallization and preliminary diffraction studies of the C-terminal domain of the DipZ homologue from Mycobacterium tuberculosis. Goldstone D, Baker EN, Metcalf P;. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:243-245. [2]. 26894533. Structure of the ectodomain of the electron transporter Rv2874 from Mycobacterium tuberculosis reveals a thioredoxin-like domain combined with a carbohydrate-binding module. Goldstone DC, Metcalf P, Baker EN;. Acta Crystallogr D Struct Biol. 2016;72:40-48. (from Pfam)

Date:

2024-10-16

Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. (from Pfam)

Date:

2024-08-14

This family of redoxins includes peroxiredoxin, thioredoxin and glutaredoxin proteins. (from Pfam)

Date:

2024-08-14

This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family. [1]. 7623667. The biogenesis of c-type cytochromes in Escherichia coli requires a membrane-bound protein, DipZ, with a protein disulphide isomerase-like domain. Crooke H, Cole J;. Mol Microbiol 1995;15:1139-1150. [2]. 7628442. Identification and characterization of a new disulfide isomerase-like protein (DsbD) in Escherichia coli. Missiakas D, Schwager F, Raina S;. EMBO J 1995;14:3415-3424. (from Pfam)

Date:

2024-10-16

This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA). [1]. 8041738. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Chae HZ, Robison K, Poole LB, Church G, Storz G, Rhee SG;. Proc Natl Acad Sci U S A 1994;91:7017-7021. (from Pfam)

Date:

2024-10-16

integral membrane cytochrome c biogenesis protein DipZ, or DsbD, is involved in disulfide bond formation of target proteins by transporting electrons from cytoplasmic thioredoxin to DsbC and DsbG

Date:

2022-09-02