Protein Family Models

The entry represents a domain found in a number of LCP (LytR-Cps2A-Psr) family proteins. LCP family is also known as TagU family. LCP family proteins have been reported to be required for the synthesis of anionic cell wall polymers [1]. [1]. 21964069. A widespread family of bacterial cell wall assembly proteins. Kawai Y, Marles-Wright J, Cleverley RM, Emmins R, Ishikawa S, Kuwano M, Heinz N, Bui NK, Hoyland CN, Ogasawara N, Lewis RJ, Vollmer W, Daniel RA, Errington J;. EMBO J. 2011;30:4931-4941. (from Pfam)

Date:

2024-10-16

This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases [1,2] that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids. [1]. 9041652. Identification of a novel phosphatase sequence motif. Stukey J, Carman GM;. Protein Sci 1997;6:469-472. [2]. 9260289. An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases. Neuwald AF;. Protein Sci 1997;6:1764-1767. [3]. 8552646. X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis. Messerschmidt A, Wever R;. Proc Natl Acad Sci U S A 1996;93:392-396. (from Pfam)

Date:

2024-10-16

type 2 phosphatidic acid phosphatase (PAP2)/LytR-CpsA-Psr (LCP) family protein may be involved in the attachment of anionic polymers to cell wall peptidoglycan in bacteria

Date:

2019-10-17

This HMM describes a domain of unknown function that is found in the predicted extracellular domain of a number of putative membrane-bound proteins. One of these is proteins psr, described as a penicillin binding protein 5 (PDP-5) synthesis repressor. Another is Bacillus subtilis LytR, described as a transcriptional attenuator of itself and the LytABC operon, where LytC is N-acetylmuramoyl-L-alanine amidase. A third is CpsA, a putative regulatory protein involved in exocellular polysaccharide biosynthesis. Besides the region of strong similarily represented by this HMM, these proteins share the property of having a short putative N-terminal cytoplasmic domain and transmembrane domain forming a signal-anchor.

Date:

2019-09-10