Protein Family Models

CcmB is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor. CcmB is required for the export of haem to the periplasm. [1]. 7635817. Escherichia coli genes required for cytochrome c maturation. Thony-Meyer L, Fischer F, Kunzler P, Ritz D, Hennecke H;. J Bacteriol 1995;177:4321-4326. (from Pfam)

Date:

2024-10-16

This model describes the cyt c biogenesis protein encoded by ccmB in bacteria. Bacterial c-type cytochromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome C.

Gene:

ccmB

Date:

2021-04-27

heme exporter protein CcmB is required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Date:

2023-03-24