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Bacterial DNA polymerase III alpha subunit finger domain
Helix-hairpin-helix motif
The HHH domain is a short DNA-binding domain [1]. [1]. 8692686. The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA. Doherty AJ, Serpell LC, Ponting CP;. Nucleic Acids Res 1996;24:2488-2497. (from Pfam)
Bacterial DNA polymerase III alpha NTPase domain
PHP domain-containing protein
The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain. [1]. 9685491. Phosphoesterase domains associated with DNA polymerases of diverse origins. Aravind L, Koonin EV;. Nucleic Acids Res 1998;26:3746-3752. (from Pfam)
DNA polymerase III subunit alpha
Catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.
DNA polymerase III alpha subunit is one of the three subunits that make up the catalytic core that contains the polymerase active site
All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
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