Protein Family Models

RelE is a family of Gram-negative bacterial antitoxins of the RelE/RelB toxin-antitoxin system. Its cognate antitoxin is family RelB, Pfam:PF04221. [1]. 19712680. Crystal structure of the antitoxin-toxin protein complex RelB-RelE from Methanococcus jannaschii. Francuski D, Saenger W;. J Mol Biol. 2009;393:898-908. [2]. 19297318. Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site. Li GY, Zhang Y, Inouye M, Ikura M;. J Biol Chem. 2009;284:14628-14636. [3]. 20728434. The structural mechanism of the inhibition of archaeal RelE toxin by its cognate RelB antitoxin. Shinohara M, Guo JX, Mori M, Nakashima T, Takagi H, Nishimoto E, Yamashita S, Tsumoto K, Kakuta Y, Kimura M;. Biochem Biophys Res Commun. 2010;400:346-351. (from Pfam)

Date:

2024-10-16

type II toxin-antitoxin system RelE/ParE family toxin similar to Escherichia coli RelE and ParE, the toxin components of toxin-antitoxin(TA) modules

Date:

2017-08-03