Protein Family Models

Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase) [1]. 7920254. Unexpected sequence similarity between nucleosidases and phosphoribosyltransferases of different specificity. Mushegian AR, Koonin EV;. Protein Sci 1994;3:1081-1088. [2]. 9351810. The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology. Mao C, Cook WJ, Zhou M, Koszalka GW, Krenitsky TA, Ealick SE;. Structure 1997;5:1373-1383. (from Pfam)

Date:

2024-10-16

PNP/MTAP phosphorylase family protein similar to purine nucleoside phosphorylase (PNP) involved in purine salvage, and S-methyl-5'-thioadenosine phosphorylase (MTAP ) that catalyzes the reversible phosphorolysis of 5'-deoxy-5'-methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate

Date:

2023-12-28

Date:

2020-10-26

This model represents the methylthioadenosine phosphorylase found in metazoa, cyanobacteria and a limited number of archaea such as Sulfolobus, Aeropyrum, Pyrobaculum, Pyrococcus, and Thermoplasma. This enzyme is responsible for the first step in the methionine salvage pathway after the transfer of the amino acid moiety from S-adenosylmethionine.

Gene:

mtnP

Date:

2022-03-28

Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate

Date:

2021-09-22