Protein Family Models

This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule [1]. [1]. 9826740. Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Hilfiker H, Hattenhauer O, Traebert M, Forster I, Murer H, Biber J;. Proc Natl Acad Sci U S A 1998;95:14564-14569. (from Pfam)

Date:

2024-10-16

This family contains phosphate regulatory proteins including PhoU. PhoU proteins are known to play a role in the regulation of phosphate uptake. The PhoU domain is composed of a three helix bundle [1]. The PhoU protein contains two copies of this domain. The domain binds to an iron cluster via its conserved E/DXXXD motif. [1]. 15716271. Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters. Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH;. J Biol Chem. 2005;280:15960-15966. (from Pfam)

Date:

2024-10-16

Na/Pi cotransporter family protein similar to Escherichia coli YjbB

Date:

2024-11-05

This HMM describes essentially the full length of an uncharacterized protein from Bacillus subtilis and correponding lengths of longer proteins from E. coli and Treponema pallidum. PSI-BLAST analysis converges to demonstrate homology to one other group of proteins, type II sodium/phosphate (Na/Pi) cotransporters. A well-conserved repeated domain in this family, approximately 60 residues in length, is also repeated in the Na/Pi cotransporters, although with greater spacing between the repeats. The two families share additional homology in the region after the first repeat, share the properly of having extensive hydrophobic regions, and may be similar in function.

Date:

2024-05-30

Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.

Date:

2024-05-02