Protein Family Models

This family represents a small domain of the E2 subunit of 2-oxo-acid dehydrogenases responsible for the binding of the E3 subunit. [1]. 8805537. Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Mande SS, Sarfaty S, Allen MD, Perham RN, Hol WG;. Structure 1996;4:277-286. (from Pfam)

Date:

2024-10-16

These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain. [1]. 8487300. Refined crystal structure of the catalytic domain of dihysrolipoyl transacetylase (E2P) from azotobacter vineelandii at 2.6 angstroms resolution. Mattevi A, Obmolova G, Kalk KH, Westphal AH, De Kok A, Hol WG;. J Mol Biol 1993;230:1183-1199. (from Pfam)

Date:

2024-10-29

This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognise the Glycine cleavage system H proteins. (from Pfam)

Date:

2024-08-14

E2 component of pyruvate dehydrogenase multienzyme complex

Gene:

aceF

Date:

2021-08-23

dihydrolipoyllysine-residue acetyltransferase (E2) component of pyruvate dehydrogenase complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)

Date:

2017-10-30

This model represents an Actinobacterial clade of E2 enzyme, a component of the 2-oxoglutarate dehydrogenase complex involved in the TCA cycle. These proteins have multiple domains including the catalytic domain (PF00198), one or two biotin domains (PF00364) and an E3-component binding domain (PF02817).

Gene:

sucB

Date:

2021-08-12