Protein Family Models

RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1]. [1]. 10673421. Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology. Palm GJ, Billy E, Filipowicz W, Wlodawer A;. Structure Fold Des 2000;8:13-23. (from Pfam)

Date:

2024-10-16

RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1]. [1]. 10673421. Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology. Palm GJ, Billy E, Filipowicz W, Wlodawer A;. Structure Fold Des 2000;8:13-23. (from Pfam)

Date:

2024-10-16

RNA 3'-terminal phosphate cyclase catalyzes the ATP-dependent conversion of terminal 3'-phosphate of RNA to the 2',3'-cyclic phosphodiester

Date:

2017-12-06

Gene:

rtcA

Date:

2021-10-15

Members of this protein family are RNA 3'-phosphate cyclase (6.5.1.4), an enzyme whose function is conserved from E. coli to human. The modification this enzyme performs enables certain RNA ligations to occur, although the full biological roll for this enzyme is not fully described. This model separates this enzyme from a related protein, present only in eukaryotes, localized to the nucleolus, and involved in ribosomal modification.

Gene:

rtcA

Date:

2024-02-27