Protein Family Models

The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin [1]. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase (Pfam:PF01014) and step two is catalysed by HIUases (Pfam:PF00576). [1]. 16462750. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. Ramazzina I, Folli C, Secchi A, Berni R, Percudani R;. Nat Chem Biol. 2006;2:144-148. (from Pfam)

Date:

2024-10-16

This domain is found in polysaccharide deacetylase. This family of polysaccharide deacetylases includes NodB (nodulation protein B from Rhizobium) which is a chitooligosaccharide deacetylase [1]. It also includes chitin deacetylase from yeast [2], and endoxylanases which hydrolyses glucosidic bonds in xylan [3]. [1]. 9163424. Molecular basis of symbiosis between Rhizobium and legumes. Freiberg C, Fellay R, Bairoch A, Broughton WJ, Rosenthal A, Perret X;. Nature 1997;387:394-401. [2]. 9133736. Cloning and expression of two chitin deacetylase genes of Saccharomyces cerevisiae. C. Mishra, C. E. Semino, K. J. McCreath, H. de la Vega, B. J. Jones, C. A. Specht & P. W. Robbins;. Yeast 1996;13:327-336. [3]. 8170399. Evidence for a general role for high-affinity non-catalytic cellulose binding domains in microbial plant cell wall hydrolases. S. J. Millward-Sadler, D. M. Poole, B. Henrissat, G. P. Hazlewood, J. H. Clarke & H. J. Gilbert;. Mol Microbiol 1994;11:375-382. (from Pfam)

Date:

2024-10-16

CE4_PuuE_SpCDA1 and UHCUDC domain-containing protein

Date:

2017-03-02

Previously thought to only proceed spontaneously, the decarboxylation of 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) has been recently been shown to be catalyzed by this enzyme in Mus musculus [1]. Homologs of this enzyme are found adjacent to and fused with uricase in a number of prokaryotes and are represented by this model.

Gene:

uraD

Date:

2024-05-15

Members of this family are PuuE, an allantoinase unrelated to AllB, described by TIGR03178.

Gene:

puuE

Date:

2021-10-26