Protein Family Models

Members of this family include regulator of ribonuclease E activity A (RraA) and 4-hydroxy-4-methyl-2-oxoglutarate (HMG)/4-carboxy- 4-hydroxy-2-oxoadipate (CHA) aldolase, also known as RraA-like protein [1]. RraA acts as a trans-acting modulator of RNA turnover, binding essential endonuclease RNase E and inhibiting RNA processing [2]. RraA-like proteins seem to contain aldolase and/or decarboxylase activity either in place of or in addition to the RNase E inhibitor functions [1]. [1]. 24359411. Biochemical and structural analysis of RraA proteins to decipher their relationships with 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipa te aldolases. Mazurkewich S, Wang W, Seah SY;. Biochemistry. 2014;53:542-553. [2]. 14499605. The X-ray structure of Escherichia coli RraA (MenG), A protein inhibitor of RNA processing. Monzingo AF, Gao J, Qiu J, Georgiou G, Robertus JD;. J Mol Biol. 2003;332:1015-1024. (from Pfam)

Date:

2024-10-16

RraA family protein such as Saccharomyces cerevisiae 4-hydroxy-4-methyl-2-oxoglutarate (HMG) aldolase, which catalyzes the aldol cleavage of HMG into 2 molecules of pyruvate

Date:

2018-04-09