Protein Family Models

ThiC is found within the thiamine biosynthesis operon. ThiC is involved in pyrimidine biosynthesis [1]. ThiC participates in the formation of 4-Amino-5-hydroxymethyl-2-methylpyrimidine from AIR, an intermediate in the de novo pyrimidine biosynthesis. Thic is a member of the radical SAM superfamily [3]. [1]. 8432721. Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in Escherichia coli K-12. Vander Horn PB, Backstrom AD, Stewart V, Begley TP;. J Bacteriol 1993;175:982-992. [2]. 10382260. Thiamin biosynthesis in prokaryotes. Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP, Taylor S, Campobasso N, Chiu HJ, Kinsland C, Reddick JJ, Xi J;. Arch Microbiol 1999;171:293-300. [3]. 18953358. Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Chatterjee A, Li Y, Zhang Y, Grove TL, Lee M, Krebs C, Booker SJ, Begley TP, Ealick SE;. Nat Chem Biol. 2008;4:758-765. (from Pfam)

Date:

2024-10-16

Catalyzes the formation of 4-amino-2-methyl-5-phosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole and S-adenosyl-L-methionine in thiamine biosynthesis

Gene:

thiC

Date:

2021-09-01

phosphomethylpyrimidine synthase ThiC catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction

Date:

2017-06-30

The thiC ortholog is designated thiA in Bacillus subtilis.

Gene:

thiC

Date:

2024-06-27