Protein Family Models

Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora [1]. [1]. 10970841. Bacterial SLH domain proteins are non-covalently anchored to the cell surface via a conserved mechanism involving wall polysaccharide pyruvylation. Mesnage S, Fontaine T, Mignot T, Delepierre M, Mock M, Fouet A;. EMBO J 2000;19:4473-4484. [2]. 8118055. Analysis of the Rhizobium meliloti genes exoU, exoV, exoW, exoT, and exoI involved in exopolysaccharide biosynthesis and nodule invasion: exoU and exoW probably encode glucosyltransferases. Becker A, Kleickmann A, Kuster H, Keller M, Arnold W, Puhler A;. Mol Plant Microbe Interact. 1993;6:735-744. (from Pfam)

Date:

2024-10-16

polysaccharide pyruvyl transferase family protein may be involved in peptidoglycan-associated polymer biosynthesis; similar to Acanthamoeba polyphaga mimivirus uncharacterized protein L143

Date:

2020-06-25

The CsaB protein (cell surface anchoring B) of Bacillus anthracis adds a pyruvoyl group to peptidoglycan-associated polysaccharide. This addition is required for proteins with an S-layer homology domain (PF00395) to bind. Within the larger group of proteins described by Pfam model PF04230, this model represents a distinct clade that nearly exactly follows the phylogenetic distribution of the S-layer homology domain (PF00395).

Gene:

csaB

Date:

2021-04-27