Protein Family Models

AmpE is a family of bacterial regulatory proteins. AmpE in conjunction with AmpD sense the effect of beta-lactam on peptidoglycan synthesis and relay this signal to AmpR. AmpR regulates the production of beta-lactamase [1]. [1]. 2691840. Signalling proteins in enterobacterial AmpC beta-lactamase regulation. Lindquist S, Galleni M, Lindberg F, Normark S;. Mol Microbiol. 1989;3:1091-1102. (from Pfam)

Gene:

ampE

Date:

2024-10-16

This family includes CobD proteins from a number of bacteria, in Salmonella this protein is called Cbib. Salmonella CobD is a different protein [1]. This protein is involved in cobalamin biosynthesis and is probably an enzyme responsible for the conversion of adenosylcobyric acid to adenosylcobinamide or adenosylcobinamide phosphate [1]. [1]. 7635831. Identification and sequence analysis of genes involved in late steps in cobalamin (vitamin B12) synthesis in Rhodobacter capsulatus. Pollich M, Klug G;. J Bacteriol 1995;177:4481-4487. See figure 6 for proposed reaction of this enzyme. [2]. 9446573. CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2. Brushaber KR, O'Toole GA, Escalante-Semerena JC;. J Biol Chem 1998;273:2684-2691. (from Pfam)

Date:

2024-10-16

CobD/CbiB family protein

Date:

2021-02-04

Date:

2020-10-26