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Aconitase C-terminal domain
Members of this family usually also match to Pfam:PF00330. This domain undergoes conformational change in the enzyme mechanism [1]. [1]. 7675781. Steric and conformational features of the aconitase mechanism. Lauble H, Stout CD;. Proteins 1995;22:1-11. (from Pfam)
aconitase family protein
Members of this family include aconitase (aconitate hydratase), 3-isopropylmalate dehydratase, and homoaconitase.
aconitate hydratase AcnA
aconitate hydratase AcnA catalyzes the reversible isomerization of citrate and isocitrate via cis-aconitate in the citric acid cycle
Catalyzes the conversion of citrate to isocitrate
This HMM represents one form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It is found in bacteria, archaea, and eukaryotic cytosol. It has been shown to act also as an iron-responsive element binding protein in animals and may have the same role in other eukaryotes.
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