Protein Family Models

This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis [1]. [1]. 7928957. Bacillus subtilis HemY is a peripheral membrane protein essential for protoheme IX synthesis which can oxidize coproporphyrinogen III and protoporphyrinogen IX. Hansson M, Hederstedt L;. J Bacteriol 1994;176:5962-5970. (from Pfam)

Date:

2024-10-16

heme biosynthesis protein HemY similar to Escherichia coli HemY, is found in heme biosynthesis gene clusters and contains tetratricopeptide repeats (TPRs)

Date:

2017-02-03

Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis.

Gene:

hemY

Date:

2024-05-30