Protein Family Models for Protein (Select 500836650) - Protein Family Models

Warning: The NCBI web site requires JavaScript to function. more...

Links from Protein

Items: 7

Select item 4122181.

Sir2 family NAD-dependent protein deacetylase

This region is characteristic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organisation and DNA damage repair processes [1].i [1]. 15128440. Sirtuins: Sir2-related NAD-dependent protein deacetylases. North BJ, Verdin E;. Genome Biol 2004;5:224. (from Pfam)

GO Terms:

Molecular Function:: NAD+ binding (GO:0070403)

Date:: 2024-10-16

Family Accession:: NF014228.5
Method:: HMM

Select item 3907462.

new record, indexing in progress

Family Accession:

Select item 3484113.

new record, indexing in progress

Family Accession:

Select item 1931414.

NAD-dependent deacetylase

Date:: 2020-10-26

Family Accession:: NF010736.0
Method:: HMM

Select item 560495.

SIR2 family NAD-dependent protein deacylase

SIR2 family NAD-dependent protein deacylase such as NAD-dependent deacetylase, which catalyzes NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose