Protein Family Models for Protein (Select 500943100) - Protein Family Models

Select item 4331311.

helix-turn-helix domain-containing protein

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Date:: 2024-04-02

Family Accession:: 15193268
Method:: Sparcle

Select item 4290712.

HTH-type transcriptional regulator Rgg, C-terminal domain

Date:: 2024-08-14

Family Accession:: NF045019.2
Method:: HMM

Select item 4125443.

helix-turn-helix domain-containing protein

This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1]. [1]. 20196080. The crystal structure of NGO0477 from Neisseria gonorrhoeae. reveals a novel protein fold incorporating a helix-turn-helix. motif.. Ren J, Sainsbury S, Nettleship JE, Saunders NJ, Owens RJ;. Proteins. 2010;78:1798-1802. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF013540.5
Method:: HMM

Select item 4069194.

new record, indexing in progress

Family Accession:

Select item 3889605.

new record, indexing in progress

Family Accession:

Select item 3475556.

new record, indexing in progress

Family Accession:

Select item 1427867.

transcriptional activator, Rgg/GadR/MutR family, C-terminal domain

This HMM describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (PFAM PF01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR (GP|2352485) is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis.

GO Terms:

Molecular Function:: DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)

Biological Process:: positive regulation of DNA-templated transcription (GO:0045893)

Date:: 2021-05-12

Family Accession:: TIGR01716.1
Method:: HMM

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