Protein Family Models

Ecotin is a broad range serine protease inhibitor, which forms homodimers. The C-terminal region contains the dimerisation motif [2]. Interestingly, the binding sites show a fluidity of protein contacts binding sites show a fluidity of protein contacts derived from ecotin's innate flexibility in fitting itself to proteases while [4,5]. [1]. 11513582. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Wang SX, Esmon CT, Fletterick RJ;. Biochemistry 2001;40:10038-10046. [2]. 11352586. The role of ecotin dimerization in protease inhibition. Eggers CT, Wang SX, Fletterick RJ, Craik CS;. J Mol Biol 2001;308:975-991. [3]. 9642073. Ecotin: a serine protease inhibitor with two distinct and interacting binding sites. Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS;. J Mol Biol 1998;279:945-957. [4]. 7757004. Ecotin: lessons on survival in a protease-filled world. McGrath ME, Gillmor SA, Fletterick RJ;. Protein Sci 1995;4:141-148. [5]. 8156987. Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex. McGrath ME, Erpel T, Bystroff C, Fletterick RJ;. EMBO J 1994;13:1502-1507. (from Pfam)

Date:

2024-10-16

ecotin is a serine protease inhibitor, inhibiting trypsin and other proteases

Date:

2016-05-13