Protein Family Models

This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known [1] and forms an incomplete beta barrel. [1]. 11525167. The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin. Xiang S, Nichols J, Rajagopalan KV, Schindelin H;. Structure 2001;9:299-310. (from Pfam)

Date:

2024-10-16

This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain. (from Pfam)

Date:

2024-08-14

This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation [1]. [1]. 11325967. X-ray crystal structure of the trimeric N-terminal domain of gephyrin. Sola M, Kneussel M, Heck IS, Betz H, Weissenhorn W;. J Biol Chem 2001;276:25294-25301. (from Pfam)

Date:

2024-10-16

Eukaryotic gephyrin-like molybdotransferase Glp and its membrane receptor GlpR bind to FtsZ and Wag31 to form a tight protein complex, which plays an important role in divisome-elongasome transition during cytokinesis in Corynebacteriales.

Gene:

glp

Date:

2023-11-25

molybdopterin molybdotransferase MoeA mediates molybdenum ligation to molybdopterin

Date:

2019-02-12

Involved in the formation of active molybdenum cofactor and the chelation of molybdenum

Gene:

moeA

Date:

2021-08-24

The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this HMM. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.

Date:

2023-10-19