Protein Family Models

This domain forms an anti-parallel beta strand structure with flanking alpha helical regions. (from Pfam)

Date:

2024-08-14

CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This HMM family, represented by CT1974 from Chlorobium tepidum, is found in the Ecoli subtype of CRISPR/Cas regions and is designated Cse3 (CRISPR/Cas Subtype Ecoli protein 3). The representative of this family from Thermus thermophilus HB8 (TTHB192) has been crystallized [2] and found to have a structure consisting of two domains with opposing parallel beta-sheets known as a beta-sheet platform. This structure is similar to those found in the Sex-lethal protein and poly(A)-binding protein. This structure is consistent with an RNA-binding function.

Gene:

cas6e

Date:

2024-08-07

type I-E CRISPR-associated protein Cas6/Cse3/CasE is an endoribonuclease that generates crRNA

Date:

2021-02-10