Protein Family Models for Protein (Select 501231846) - Protein Family Models

Select item 4304311.

Ribonucleotide synthetase preATP-grasp domain

This domain precedes the ATP-grasp domain in a number of ribonucleotide synthetases [1-5]. Paper describing PDB structure 1b6r. [1]. 10569930. Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily. Thoden JB, Kappock TJ, Stubbe J, Holden HM;. Biochemistry. 1999;38:15480-15492. Paper describing PDB structure 1eyz. [2]. 10913290. Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase. Thoden JB, Firestine S, Nixon A, Benkovic SJ, Holden HM;. Biochemistry. 2000;39:8791-8802. Paper describing PDB structure 1kj8. [3]. 11953435. PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site. Thoden JB, Firestine SM, Benkovic SJ, Holden HM;. J Biol Chem. 2002;277:23898-23908. Paper describing PDB structure 3eth. [4]. 19053251. Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli. Thoden JB, Holden HM, Firestine SM;. Biochemistry. 2008;47:13346-13353. Paper describing PDB structure 3k5h. [5]. 20050602. Structural and functional studies of Aspergillus clavatus N(5)-carboxyaminoimidazole ribonucleotide synthetase . Thoden JB, Holden HM, Paritala H, Firestine SM;. Biochemistry. 2010;49:752-760. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF046885.1
Method:: HMM

Select item 4259442.

Phosphoribosylaminoimidazole carboxylase C-terminal domain

This entry represents the C-terminal domain of the PurK enzyme. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF037629.5
Method:: HMM

Select item 4126383.

ATP-grasp domain-containing protein

This family does not contain all known ATP-grasp domain members. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity. [1]. 9416615. A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. Galperin MY, Koonin EV;. Protein Sci 1997;6:2639-2643. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF014298.5
Method:: HMM

Select item 4064204.

new record, indexing in progress

Family Accession:

Select item 3897365.

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Family Accession:

Select item 3626686.

new record, indexing in progress

Family Accession:

Select item 3475377.

new record, indexing in progress

Family Accession:

Select item 2309208.

5-(carboxyamino)imidazole ribonucleotide synthase

5-(carboxyamino)imidazole ribonucleotide synthase catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR)

Date:: 2023-03-03

Family Accession:: 11481947
Method:: Sparcle

Select item 1584369.

5-(carboxyamino)imidazole ribonucleotide synthase

Date:: 2020-10-26

Family Accession:: NF004676.0
Method:: HMM

Select item 15782010.

5-(carboxyamino)imidazole ribonucleotide synthase

GO Terms:

Molecular Function:: phosphoribosylaminoimidazole carboxylase activity (GO:0004638)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: 'de novo' IMP biosynthetic process (GO:0006189)

Molecular Function:: metal ion binding (GO:0046872)

Date:: 2021-07-30

Family Accession:: NF004679.0
Method:: HMM

Select item 14178111.

5-(carboxyamino)imidazole ribonucleotide synthase

Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, N5-carboxyaminoimidazole ribonucleotide synthetase (EC 6.3.4.18), which hydrolyzes ATP and converts AIR to N5-CAIR. PurE converts N5-CAIR to CAIR. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP.

Gene:: purK

GO Terms:

Biological Process:: purine ribonucleotide biosynthetic process (GO:0009152)

Cellular Component:: phosphoribosylaminoimidazole carboxylase complex (GO:0009320)

Molecular Function:: 5-(carboxyamino)imidazole ribonucleotide synthase activity (GO:0034028)

Date:: 2021-12-08

Family Accession:: TIGR01161.1
Method:: HMM

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