Protein Family Models

This domain represents the N-terminal of NAD(P)H-quinone oxidoreductase subunit 2 (or subunit B), part of the P-module (pumping) of the photosynthetic complex I from plants and cyanobacteria, which is structurally and functionally related to the respiratory complex I from mitochondria and bacteria. It is involved in the electron transfer between photosynthetic complex I and photosystem I [1]. Paper describing PDB structure 6hum. [1]. 30573545. Structural adaptations of photosynthetic complex I enable ferredoxin-dependent electron transfer. Schuller JM, Birrell JA, Tanaka H, Konuma T, Wulfhorst H, Cox N, Schuller SK, Thiemann J, Lubitz W, Setif P, Ikegami T, Engel BD, Kurisu G, Nowaczyk MM;. Science. 2019;363:257-260. (from Pfam)

Date:

2024-10-16

Members of this family include multiple membrane-spanning proteins associated with proton translocation. These include NADH ubiquinone oxidoreductase subunits NuoL, NuoN, and NuoM, hydrogenase components HyfB, HyfD, and HyfF, as well as subunits of carbon monoxide dehydrogenase, F420 dehydrogenase, etc, as well as Na+/H+ antiporter subunits.

Date:

2024-10-16

NAD(P)H-quinone oxidoreductase subunit 2 shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain

Date:

2018-11-09

This HMM describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone.

Gene:

nuoN

Date:

2024-05-30

Date:

2020-10-26