Protein Family Models

This domain is found in uncharacterised proteins from bacteria, archaea and eukaryotes, including NTF2-Like SgcJ protein from Streptomyces carzinostaticus, which plays a role in the biosynthesis of the 9-membered enediyne antitumor antibiotic C-1027. It shows a cone-like alpha+beta barrel structure with a long N-terminal alpha- helix, a curved six-stranded antiparallel beta-sheet and two additional shorter alpha-helices. Its specific function is still unkown [1]. [1]. 27406907. Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, Joachimiak A, Phillips GN, Shen B;. J Antibiot (Tokyo). 2016;69:731-740. (from Pfam)

Date:

2024-10-16

This family contains a large number of proteins that share the SnoaL fold. (from Pfam)

Date:

2024-08-14

This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers [2]. [1]. 12603201. Differential functional properties of calmodulin-dependent protein kinase IIgamma variants isolated from smooth muscle. Gangopadhyay SS, Barber AL, Gallant C, Grabarek Z, Smith JL, Morgan KG;. Biochem J 2003;372:347-357. [2]. 14993460. CaMKII, an enzyme on the move: regulation of temporospatial localization. Griffith LC, Lu CS, Sun XX;. Mol Interv 2003;3:386-403. (from Pfam)

Date:

2024-10-16