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frataxin domain-containing protein
This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport. [1]. 8931268. Friedreich's ataxia protein: phylogenetic evidence for mitochondrial dysfunction. Gibson TJ, Koonin EV, Musco G, Pastore A, Bork P;. Trends Neurosci 1996;19:465-468. (from Pfam)
iron donor protein CyaY
iron donor protein CyaY is involved in iron-sulfur (Fe-S) cluster assembly and may act as a regulator of Fe-S biogenesis
Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set.
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