Protein Family Models

YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase [1]. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins [2]. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures. [1]. 18586829. YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase. Sengupta S, Nagaraja V;. Nucleic Acids Res. 2008;36:4310-4316. [2]. 12211008. NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins. Ramelot TA, Cort JR, Yee AA, Semesi A, Edwards AM, Arrowsmith CH, Kennedy MA;. Proteins. 2002;49:289-293. (from Pfam)

Gene:

yacG

Date:

2024-10-16

DNA gyrase inhibitor YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA

Date:

2023-02-23

Inhibits supercoiling by DNA gyrase by binding to the GyrB subunit

Gene:

yacG

Date:

2021-08-27