Protein Family Models

This entry includes Glycine dehydrogenases, also known as glycine cleavage system P protein, which bind the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. The monomer consists of two domains, a large domain and a small domain. This entry represents the small domain, which has a complex alpha/beta structure [1,2]. Paper describing PDB structure 1wyt. [1]. 15791207. Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia. Nakai T, Nakagawa N, Maoka N, Masui R, Kuramitsu S, Kamiya N;. EMBO J. 2005;24:1523-1536. Paper describing PDB structure 4lgl. [2]. 24121504. Structure of the homodimeric glycine decarboxylase P-protein from Synechocystis sp. PCC 6803 suggests a mechanism for redox regulation. Hasse D, Andersson E, Carlsson G, Masloboy A, Hagemann M, Bauwe H, Andersson I;. J Biol Chem. 2013;288:35333-35345. (from Pfam)

Date:

2024-10-16

This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T [2]. The reaction catalysed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2 [1]. 7498764. Genetics of the synthesis of serine from glycine and the utilization of glycine as sole nitrogen source by Saccharomyces cerevisiae. Sinclair DA, Dawes IW;. Genetics 1995;140:1213-1222. [2]. 8181752. Characterization of the Escherichia coli gcv operon. Stauffer LT, Fogarty SJ, Stauffer GV;. Gene 1994;142:17-22. (from Pfam)

Date:

2024-10-16

This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment.

Gene:

gcvP

Date:

2021-04-27