Protein Family Models

Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus [1,2]. [1]. 1860816. Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica. Michiels T, Vanooteghem JC, Lambert de Rouvroit C, China B, Gustin A, Boudry P, Cornelis GR;. J Bacteriol 1991;173:4994-5009. [2]. 22349221. Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system. Lountos GT, Tropea JE, Waugh DS;. Acta Crystallogr D Biol Crystallogr. 2012;68:201-209. (from Pfam)

Date:

2024-10-16

This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) [1] and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis [2]. [1]. 22000520. Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase. Roumestand C, Leiba J, Galophe N, Margeat E, Padilla A, Bessin Y, Barthe P, Molle V, Cohen-Gonsaud M;. Structure. 2011;19:1525-1534. [2]. 22275220. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T;. Sci Signal. 2012;5:ra7. (from Pfam)

Date:

2024-10-16

The FHA (Forkhead-associated) domain is a phosphopeptide binding motif [2]. [1]. 7482699. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Hofmann K, Bucher, P;. Trends Biochem Sci 1995;20:347-349. [2]. 10518219. The FHA domain is a modular phosphopeptide recognition motif. Durocher D, Henckel J, Fersht AR, Jackson SP;. Mol Cell. 1999;4:387-394. [3]. 12564991. Bacterial FHA domains: neglected players in the phospho-threonine signalling game?. Pallen M, Chaudhuri R, Khan A;. Trends Microbiol 2002;10:556-563. (from Pfam)

Date:

2024-10-16

DUF3662 and FHA domain-containing protein

Date:

2017-03-02