Protein Family Models

PhzC/PhzF is involved in dimerisation of two 2,3-dihydro-3-oxo-anthranilic acid molecules to create PCA by P. fluorescens [1]. This family also contains Swiss:P28176, though there is no significant sequence similarity to Pfam:PF00303 members. This family appears to be distantly related to Pfam:PF01678, including containing a weak internal duplication. However members of this family do not contain the conserved cysteines that are hypothesised to be active site residues (Bateman A pers obs). [1]. 11562236. Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid. McDonald M, Mavrodi DV, Thomashow LS, Floss HG;. J Am Chem Soc 2001;123:9459-9460. (from Pfam)

Date:

2024-10-16

PhzF family phenazine biosynthesis protein is involved in the production of phenazine derivative antibiotic and antifungal compounds; similar to Pseudomonas aeruginosa trans-2,3-dihydro-3-hydroxyanthranilate (DHHA) isomerase, which catalyzes the condensation of two DHHA molecules to form the phenazine ring system

Date:

2023-03-16

Members of this family show a distant global similarity to diaminopimelate epimerases, which can be taken as the outgroup. One member of this family has been shown to act as an enzyme in the biosynthesis of the antibiotic phenazine in Pseudomonas aureofaciens. The function in other species is unclear.

Date:

2022-03-28